Hypoxia inducible factors in cancer stem cells
نویسندگان
چکیده
منابع مشابه
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specif...
متن کاملHypoxia-inducible factors in stem cells and cancer
Cellular properties are influenced by complex factors inherent to their microenvironments. While oxygen deprivation (hypoxia) occurs in tumours because of rapid cell proliferation and aberrant blood vessel formation, embryonic cells develop in a naturally occurring hypoxic environment. Cells respond to hypoxia by stabilizing hypoxia-inducible factors (HIFs), which are traditionally viewed to fu...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2010
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6605551